Technology Process of anti-(4R,5R,6E,8E)-1-(tert-butyldiphenylsilyloxy)-4,6,8,10,10-pentamethyl-3-methyleneundeca-6,8-dien-5-ol
There total 28 articles about anti-(4R,5R,6E,8E)-1-(tert-butyldiphenylsilyloxy)-4,6,8,10,10-pentamethyl-3-methyleneundeca-6,8-dien-5-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 1.5h;
DOI:10.1039/b608193m
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / LiAlH4 / diethyl ether / 4 h / 0 °C
2: 90 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / 0 °C
3: 74 percent / indium; La(OTf)3 / tetrahydrofuran; H2O / 16 h / 20 °C
4: 90 percent / Dess-Martin periodinane / CH2Cl2 / 3 h / 0 °C
5: 85 percent / NaBH4; CeCl3*7H2O / tetrahydrofuran; H2O / 3 h / 0 °C
6: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
7: 4-dimethylamino pyridine; DCC / CH2Cl2 / 12 h / 0 - 20 °C
8: 94 percent / LiOH / tetrahydrofuran; H2O / 20 °C
9: 89 percent / imidazole / dimethylformamide / 1.5 h / 0 °C
With
1H-imidazole; dmap; indium; lithium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; tetrabutyl ammonium fluoride; Dess-Martin periodane; dicyclohexyl-carbodiimide; lanthanum(lll) triflate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
5: Luche reduction;
DOI:10.1039/b608193m
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 79 percent / triethyl amine; 4-dimethylamino pyridine / CH2Cl2 / 3 h / 0 - 20 °C
2: 78 percent / AgNO3 / dimethylformamide / 12 h / 0 - 20 °C
3: 94 percent / K2CO3 / methanol / 16 h / 20 °C
4: 74 percent / NBS; triphenylphosphine / CH2Cl2 / 0.75 h / -78 - 0 °C
5: 73 percent / indium; La(OTf)3 / H2O; tetrahydrofuran / 96 h / 20 °C
6: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C
7: 89 percent / imidazole / dimethylformamide / 1.5 h / 0 °C
With
1H-imidazole; dmap; indium; N-Bromosuccinimide; tetrabutyl ammonium fluoride; potassium carbonate; silver nitrate; triethylamine; triphenylphosphine; lanthanum(lll) triflate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b608193m
