Technology Process of Ac-Phe-MeA-MeA-MeA-Val-Gly-OH
There total 16 articles about Ac-Phe-MeA-MeA-MeA-Val-Gly-OH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol; ethyl acetate;
for 3h;
under 1471.02 - 2206.5 Torr;
DOI:10.1021/ja00037a010
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 86 percent / acetonitrile / Heating
2: 95 percent / H2 / 5percent Pd/C / methanol / 4 h
3: tetrahydrofuran / 1.) -12 deg C, 1 h, 2.) RT, 8 h
4: H2 / 5percent Pd/C / methanol / 4 h
5: pyridine / toluene / 4 h
6: 79 percent / TFA / 1 h
7: 1.) HOBt hydrate, DCC, 2.) N-methylmorpholine / 1.) DMF, from 25 to 40 deg C, 1 h, 2.) DMF, RT, 96 h
8: 91 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / 3 h / 1471.02 - 2206.5 Torr
With
4-methyl-morpholine; pyridine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/ja00037a010
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-methylmorpholine / dimethylformamide; CH2Cl2 / 0.17 h / -20 °C
2: dimethylformamide; CH2Cl2 / 2 h / -10 - 20 °C
3: 99 percent / 4 N HCl / ethyl acetate / 0.75 h
4: 1.) HOBt hydrate, DCC, 2.) N-methylmorpholine / 1.) DMF, from 25 to 40 deg C, 1 h, 2.) DMF, RT, 96 h
5: 91 percent / H2 / 10percent Pd/C / methanol; ethyl acetate / 3 h / 1471.02 - 2206.5 Torr
With
4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00037a010
