5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

Base Information

Chemical Name:5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide
CAS No.:1450913-60-6
Molecular Formula:C₂₁H₂₃ClN₄O₅
Molecular Weight:446.89
Hs Code.:

Synonyms:5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

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Chemical Property of 5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

Chemical Property:

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Technology Process of 5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

There total 8 articles about 5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450913-59-3
ethyl 5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxylate

: 1450913-60-6
5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

Guidance literature:: With amino compound; In methanol; at 20 ℃;

Reference yield:

: 6109-54-2
2,5-bis(benzyloxy)benzaldehyde

: 1450913-60-6
5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: magnesium bromide ethyl etherate / benzene; diethyl ether / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 60 h / Reflux

3: hydrogen; palladium on activated charcoal / ethanol / 20 °C

4: phenol; sodium hydroxide / 120 °C / Microwave irradiation

5: sodium hydroxide / 70 °C

6: ammonium hydroxide / methanol; water / 20 °C

With ammonium hydroxide; palladium on activated charcoal; hydrogen; potassium carbonate; magnesium bromide ethyl etherate; sodium hydroxide; phenol; In methanol; diethyl ether; ethanol; water; acetonitrile; benzene;

Reference yield:

: 99370-68-0
5-hydroxy-2-benzofuran-carboxylic acid ethyl ester

: 1450913-60-6
5-(3-(2-(3-(3-chlorophenyl)ureido)ethylamino)-2-hydroxypropoxy)benzofuran-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: phenol; sodium hydroxide / 120 °C / Microwave irradiation

2: sodium hydroxide / 70 °C

3: ammonium hydroxide / methanol; water / 20 °C

With ammonium hydroxide; sodium hydroxide; phenol; In methanol; water;