ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate
• CAS No.: 136709-51-8
• Molecular Formula: C₂₅H₃₉N₃O₆
• Molecular Weight: 477.601
• Mol file: 136709-51-8.mol

Synonyms:ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate

Chemical Property of ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate

There total 4 articles about ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.25%

di-tert-butyl (E)-azodicarboxylate (870-50-8) + N-benzyl isonipecotic acid ethyl ester (24228-40-8) → ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate (136709-51-8)

Guidance literature:

N-benzyl isonipecotic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

di-tert-butyl (E)-azodicarboxylate; In tetrahydrofuran; for 4h; Enzymatic reaction;

Reference yield:

di-tert-butyl-diazodicarboxylate (870-50-8) + N-benzyl isonipecotic acid ethyl ester (24228-40-8) → ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate (136709-51-8)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) Et₂O, hexane, -70 deg C, 40 min, 2.) Et₂O, hexane, -70 deg C to RT, 2.5 h;

DOI:10.1021/jm00091a007

Reference yield:

4-carbethoxypiperidine (1126-09-6) → ethyl 1-benzyl-4-hydrazino>piperidine-4-carboxylate (136709-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / Ambient temperature

2: 1.) LDA / 1.) Et₂O, hexane, -70 deg C, 40 min, 2.) Et₂O, hexane, -70 deg C to RT, 2.5 h

With potassium carbonate; lithium diisopropyl amide; In acetone;

DOI:10.1021/jm00091a007

upstream raw materials:

di-tert-butyl-diazodicarboxylate

N-benzyl isonipecotic acid ethyl ester

4-carbethoxypiperidine

benzyl bromide

Downstream raw materials:

ethyl 1-benzyl-4-(3-methyl-1,2,4-triazol-1-yl)piperidine-4-carboxylate

ethyl 1-benzyl-4-(1,2,4-triazol-1-yl)piperidine-4-carboxylate

[1-Benzyl-4-(3-methyl-[1,2,4]triazol-1-yl)-piperidin-4-yl]-methanol

(1-Benzyl-4-[1,2,4]triazol-1-yl-piperidin-4-yl)-methanol