(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

Base Information

Chemical Name:(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol
CAS No.:1190754-14-3
Molecular Formula:C₂₅H₃₂O₃Si
Molecular Weight:408.613
Hs Code.:

Synonyms:(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

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Chemical Property of (3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

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Technology Process of (3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

There total 4 articles about (3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 99333-00-3
(+)-(1R,6S,7S)-7-diphenyl-t-butylsiloxymethyl-8-oxabicyclo-<4.3.0>non-3-en-9-one

: 1190754-14-3
(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1.33333h; Inert atmosphere;
DOI:10.1002/chem.201505093

Reference yield:

: 99315-76-1
(5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone

: 1190754-14-3
(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylaluminum chloride; TfN([Al(Me)Cl]2) / hexane; dichloromethane; toluene / 48 h / 60 °C / Sealed tube

2: diisobutylaluminium hydride / dichloromethane / 1.33 h / -78 °C / Inert atmosphere

With TfN([Al(Me)Cl]2); dimethylaluminum chloride; diisobutylaluminium hydride; In hexane; dichloromethane; toluene;
DOI:10.1002/chem.201505093

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1190754-14-3
(3S,3aS,7aR)-3-((tert-butyldiphenylsilyloxy)methyl)-1,3,3a,4,7,7a-hexahydroisobenzofuran-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: dimethylaluminum chloride; TfN([Al(Me)Cl]2) / hexane; dichloromethane; toluene / 48 h / 60 °C / Sealed tube

3: diisobutylaluminium hydride / dichloromethane / 1.33 h / -78 °C / Inert atmosphere

With 1H-imidazole; TfN([Al(Me)Cl]2); dimethylaluminum chloride; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201505093