ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

Base Information

Chemical Name:ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate
CAS No.:1616764-52-3
Molecular Formula:C₂₈H₄₂N₄O₃
Molecular Weight:482.666
Hs Code.:

Synonyms:ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

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Chemical Property of ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

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Technology Process of ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

There total 5 articles about ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126795-15-0
N₁-((1R,1'R,3R,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)benzene-1,2-diamine

: 2949-22-6
Glycine ethyl ester isocyanate

: 1616764-52-3
ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

Guidance literature:: In dichloromethane; at 25 ℃; for 1.5h; Cooling with ice;

Reference yield:

: 1384190-01-5
(1R,1'R,3R,3'R,5S,5'S)-9'-aza[3,9'-bi(bicyclo[3.3.1]nonan)]-3'-amine acetate

: 1616764-52-3
ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C / 2585.81 Torr

3: dichloromethane / 1.5 h / 25 °C / Cooling with ice

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: (1R,1'R,3r,5S,5'S)-9'-aza[3,9′-bi(bicyclo[3.3.1]nonan)]-3'-one

: 1616764-52-3
ethyl 2-(3-(2-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-ylamino)phenyl)ureido)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; hydroxylamine / tetrahydrofuran; water / 17 h / 18 °C / Reflux

2: hydrogen; platinum(IV) oxide / tetrahydrofuran / 25858.1 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 110 °C

4: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 25 °C / 2585.81 Torr

5: dichloromethane / 1.5 h / 25 °C / Cooling with ice

With platinum(IV) oxide; palladium 10% on activated carbon; hydrogen; hydroxylamine; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;