3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one

Base Information

• Chemical Name: 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one
• CAS No.: 1414861-13-4
• Molecular Formula: C₁₅H₁₃NO₅
• Molecular Weight: 287.272
• Mol file: 1414861-13-4.mol

Synonyms:3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one

Chemical Property of 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one

There total 2 articles about 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(4-Nitrophenyl)acetylene (937-31-5) + 5-hydroxy-4-methoxy-2-methylpyrylium trifluoromethanesulfonate (141972-04-5) → 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one (1414861-13-4)

Guidance literature:

With N,N-diisopropylaniline; In chloroform; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/ol302892g

Reference yield:

allomaltol (644-46-2) → 3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one (1414861-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 4 h / Reflux

2: N,N-diisopropylaniline / chloroform / 0.5 h / 100 °C / Microwave irradiation

With N,N-diisopropylaniline; In dichloromethane; chloroform;

DOI:10.1021/ol302892g

Reference yield:

3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one (1414861-13-4) → 2-hydroxy-7-methoxy-5-methyl-4-(4-nitrophenyl)-cyclohepta-2,4,6-trienone (1414861-25-8) + 2,7-dihydroxy-4-methyl-5-(4-nitrophenyl)cyclohepta-2,4,6-trienone (1414861-24-7)

Guidance literature:

3-methoxy-5-methyl-6-(4-nitrophenyl)-8-oxabicyclo[3.2.1]octa-3,6-dien-2-one; With boron tribromide; In dichloromethane; at 0 ℃; for 0.166667h;

With water; In dichloromethane; at 0 - 20 ℃; for 1.03333h; Overall yield = 81 %; Overall yield = 23.3 mg;

DOI:10.1021/ol302892g

upstream raw materials:

(4-Nitrophenyl)acetylene

5-hydroxy-4-methoxy-2-methylpyrylium trifluoromethanesulfonate

allomaltol

Downstream raw materials:

2-hydroxy-7-methoxy-5-methyl-4-(4-nitrophenyl)-cyclohepta-2,4,6-trienone

2,7-dihydroxy-4-methyl-5-(4-nitrophenyl)cyclohepta-2,4,6-trienone