2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

Base Information

Chemical Name:2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate
CAS No.:1215106-83-4
Molecular Formula:C₁₆H₁₀F₄N₂O₅S
Molecular Weight:418.325
Hs Code.:

Synonyms:2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

There total 9 articles about 2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.8%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1215106-82-3
2-(4-fluorophenyl)-5-hydroxy-N-methylfuro[2,3-c]pyridine-3-carboxamide

: 1215106-83-4
2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 0 - 20 ℃;

Reference yield:

: 725256-57-5
6-benzyloxy-3-hydroxypyridine

: 1215106-83-4
2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 25 °C

1.2: 2 h / 20 °C

2.1: tert.-butyl lithium / tetrahydrofuran / -78 °C

2.2: -78 °C

3.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 80 °C

4.1: trifluoroacetic acid / 1,2-dichloro-ethane / 5 h / 20 °C

5.1: potassium carbonate; sodium acetate; copper(II) choride dihydrate / palladium dichloride / 20 °C / 15514.9 Torr / Parr bomb

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 0.33 h / 20 °C

9.1: pyridine / 0 - 20 °C

With pyridine; copper(l) iodide; copper(II) choride dihydrate; water; hydrogen; tert.-butyl lithium; sodium acetate; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1215106-75-4
2-(benzyloxy)-5-(methoxymethoxy)pyridine

: 1215106-83-4
2-(4-fluorophenyl)-3-(methylcarbamoyl)furo[2,3-c]pyridin-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tert.-butyl lithium / tetrahydrofuran / -78 °C

1.2: -78 °C

2.1: triethylamine; copper(l) iodide / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 80 °C

3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 5 h / 20 °C

4.1: potassium carbonate; sodium acetate; copper(II) choride dihydrate / palladium dichloride / 20 °C / 15514.9 Torr / Parr bomb

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 0.33 h / 20 °C

8.1: pyridine / 0 - 20 °C

With pyridine; copper(l) iodide; copper(II) choride dihydrate; water; hydrogen; tert.-butyl lithium; sodium acetate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;