4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

Base Information

Chemical Name:4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate
CAS No.:84701-27-9
Molecular Formula:C₂₃H₂₃N₃O₆S
Molecular Weight:469.518
Hs Code.:

Synonyms:4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

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Chemical Property of 4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

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Technology Process of 4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

There total 5 articles about 4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 92761-33-6
1,5-(Z)-4,7-diaza-7-<1-(4-nitrobenzyloxycarbonyl)-2-methylprop-2-enyl>-3-phenoxymethyl-2-thiabicyclo<3.2.0>hept-3-en-6-one

: 84701-27-9
4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

Guidance literature:: With hydrogen; Wilkinson's catalyst; In benzene; for 24h; under 760 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)91148-2

Reference yield:

: 58244-55-6
4-nitrobenzyl(2S,5R,6R)-3,3-dimethyl-7-oxo-6-phenoxyacetamido-1-aza-4-thiabicyclo<3.2.0>heptane-2-carboxylate

: 84701-27-9
4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / MCPBA, O₂ / CH₂Cl₂ / 0.58 h / Ambient temperature

2: 91 percent / trimethyl phosphite / toluene / 4.17 h / Heating

3: 87 percent / H₂ / Wilkinson's catalyst / benzene / 24 h / 760 Torr / Ambient temperature

With hydrogen; oxygen; 3-chloro-benzenecarboperoxoic acid; phosphorous acid trimethyl ester; Wilkinson's catalyst; In dichloromethane; toluene; benzene;
DOI:10.1016/S0040-4020(01)91148-2

Reference yield:

: 132-98-9
penicillin V potassium

: 84701-27-9
4-nitrobenzyl(2R)-3-methyl-2-<(1R,5R)-7-oxo-3-phenoxymethyl-4-thia-2,6-diazabicyclo<3.2.0>hept-2-en-6-yl>butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaI / dimethylformamide / 15 h / Ambient temperature

2: 92 percent / MCPBA, O₂ / CH₂Cl₂ / 0.58 h / Ambient temperature

3: 91 percent / trimethyl phosphite / toluene / 4.17 h / Heating

4: 87 percent / H₂ / Wilkinson's catalyst / benzene / 24 h / 760 Torr / Ambient temperature

With hydrogen; oxygen; 3-chloro-benzenecarboperoxoic acid; sodium iodide; phosphorous acid trimethyl ester; Wilkinson's catalyst; In dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4020(01)91148-2