2-OXO-INDOLINE-7-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-OXO-INDOLINE-7-CARBOXYLIC ACID
• CAS No.: 25369-43-1
• Molecular Formula: C9H7NO3
• Molecular Weight: 177.159
• Hs Code.: 2933790090
• Mol file: 25369-43-1.mol

Synonyms:2-Oxo-2,3-dihydro-1H-indole-7-carboxylic acid;7-Carboxyoxindole;

Chemical Property of 2-OXO-INDOLINE-7-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.06E-08mmHg at 25°C
• Refractive Index: 1.634
• Boiling Point: 445 °C at 760 mmHg
• Flash Point: 222.9 °C
• PSA: 66.40000
• Density: 1.433 g/cm³
• LogP: 1.01740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

90.0%Min ^*data from raw suppliers

2-Oxo-indoline-7-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-OXO-INDOLINE-7-CARBOXYLIC ACID

There total 2 articles about 2-OXO-INDOLINE-7-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl oxindole-7-carboxylate (380427-39-4) → 2-oxoindoline-7-carboxylic acid (25369-43-1)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2006.12.006

Reference yield:

→ 2-oxoindoline-7-carboxylic acid (25369-43-1)

Guidance literature:

3-Hydroxy-chinolin-8-carbonsaeure, 30percentig. wss. H2O2, Eg., 80grad;

Reference yield: 32.0%

2-oxoindoline-7-carboxylic acid (25369-43-1) + (+/-)-α-aminoglutarimide (2353-44-8,673485-72-8) → N-(2,6-dioxopiperidin-3-yl)-2-oxoindoline-7-carboxamide

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 25 ℃;

upstream raw materials:

methyl oxindole-7-carboxylate

Downstream raw materials:

C₁₅H₁₁ClN₂O₂

Refernces