2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

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Chemical Name:2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide
CAS No.:1295626-57-1
Molecular Formula:C₂₆H₃₀N₂O₃
Molecular Weight:418.536
Hs Code.:

Synonyms:2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

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Chemical Property of 2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

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Technology Process of 2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

There total 9 articles about 2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295626-37-7
2-(1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1295626-57-1
2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

: 1295626-38-8
2-[(S)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

Guidance literature:: 2-(1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl)ethanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

(S)-1-phenyl-ethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 27h; Inert atmosphere;
DOI:10.1021/jm200070e

Reference yield:

: 6342-80-9
4,5-dimethoxyindanone

: 1295626-57-1
2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 24 h / Reflux; Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere

3.1: methanol; potassium tert-butylate / 1,2-dimethoxyethane / 24.5 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 - 10 °C / Inert atmosphere

4.2: 16 h / -78 - 20 °C / Inert atmosphere

5.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 27 h / 0 - 20 °C / Inert atmosphere

With methanol; aluminum (III) chloride; lithium hydroxide monohydrate; potassium tert-butylate; sodium hexamethyldisilazane; trimethylamine hydrochloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200070e

Reference yield:

: 1295626-30-0
4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-indene-1-carbonitrile

: 1295626-57-1
2-[(R)-1-cyano-4-cyclopentyloxy-5-methoxy-2,3-dihydro-1H-inden-1-yl]-N-[(S)-1-phenylethyl]ethanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 6 h / -78 - 10 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 27 h / 0 - 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200070e