1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester
• CAS No.: 156779-19-0
• Molecular Formula: C₁₄H₁₇NO₂S
• Molecular Weight: 263.36
• Mol file: 156779-19-0.mol

Synonyms:1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester

Chemical Property of 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester

There total 4 articles about 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-benzyl-6-oxopiperidine-3-carboxylic acid methyl ester (156779-11-2) → 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester (156779-19-0)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran;

DOI:10.1021/jo00092a015

Reference yield:

(E/Z)-methyl 3-(benzylamino)acrylate (14376-92-2) → 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester (156779-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 16 h / 66 °C

2: 98 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethanol / 2280 Torr

3: 99 percent / Lawesson's reagent / tetrahydrofuran

With Lawessons reagent; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00092a015

Reference yield:

1,4,5,6-tetrahydro-6-oxo-1-(phenylmethyl)-3-pyridinecarboxylic acid methyl ester (156779-10-1) → 1-Benzyl-6-thioxo-piperidine-3-carboxylic acid methyl ester (156779-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethanol / 2280 Torr

2: 99 percent / Lawesson's reagent / tetrahydrofuran

With Lawessons reagent; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jo00092a015

upstream raw materials:

1-benzyl-6-oxopiperidine-3-carboxylic acid methyl ester

(E/Z)-methyl 3-(benzylamino)acrylate

1,4,5,6-tetrahydro-6-oxo-1-(phenylmethyl)-3-pyridinecarboxylic acid methyl ester

benzylamine