(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

Base Information

Chemical Name:(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide
CAS No.:279261-09-5
Molecular Formula:C₃₅H₃₆N₂O₆S
Molecular Weight:612.747
Hs Code.:

Synonyms:(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

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Chemical Property of (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

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Technology Process of (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

There total 4 articles about (S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955-44-2
2-(α-hydroxy-4-nitrobenzyl)pyridine

: 279261-09-5
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd/C / ethanol; ethyl acetate / 20 °C

2: hexane; ethanol

3: 273 mg / Et₃N / tetrahydrofuran / 40 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; ethyl acetate;
DOI:10.1248/cpb.52.818

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 279261-09-5
(S)-7-[4-(2-butoxyethoxy)phenyl]-N-{4-[hydroxy(pyridin-2-yl)methyl]phenyl}-2,3-dihydro-1-benzothiepine-4-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

1.2: 34 percent / diethyl ether; hexane; tetrahydrofuran / 3 h / -78 °C

2.1: 95 percent / H₂ / Pd/C / ethanol; ethyl acetate / 20 °C

3.1: hexane; ethanol

4.1: 273 mg / Et₃N / tetrahydrofuran / 40 h / 20 °C

With n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; hexane; ethyl acetate;
DOI:10.1248/cpb.52.818