4-Thiazolecarboxylicacid,4,5-dihydro-,ethylester,(4R)-(9CI)

Base Information

• Chemical Name: 4-Thiazolecarboxylicacid,4,5-dihydro-,ethylester,(4R)-(9CI)
• CAS No.: 206876-90-6
• Molecular Formula: C6H9 N O2 S
• Molecular Weight: 159.209
• Mol file: 206876-90-6.mol

Synonyms:4-Thiazolecarboxylicacid, 4,5-dihydro-, ethyl ester, (R)-

Chemical Property of 4-Thiazolecarboxylicacid,4,5-dihydro-,ethylester,(4R)-(9CI)

Chemical Property:

• PSA: 63.96000
• LogP: 0.12880

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylicacid,4,5-dihydro-,ethylester,(4R)-(9CI)

There total 1 articles about 4-Thiazolecarboxylicacid,4,5-dihydro-,ethylester,(4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

L-cysteine ethyl ester hydrochloride (868-59-7) + 1-(tert-butylimino-methyl)-1,3-dimethylurea hydrochloride → N,N'-Dimethylurea (96-31-1) + ethyl (R)-4,5-dihydrothiazole-4-carboxylate (206876-90-6)

Guidance literature:

With triethylamine; In dichloromethane; Heating;

DOI:10.1021/ol035995f

Reference yield: 41.0%

ethyl (R)-4,5-dihydrothiazole-4-carboxylate (206876-90-6) + 5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (764667-64-3) → (2R,5S,6R)-7-Oxo-6-[2-(2,4,5-trifluoro-phenyl)-acetyl]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethyl ester

Guidance literature:

With hydrogenchloride; In benzene; Heating;

DOI:10.1021/ja046488b

upstream raw materials:

L-cysteine ethyl ester hydrochloride