3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide

Base Information

• Chemical Name: 3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide
• CAS No.: 349643-61-4
• Molecular Formula: C₁₆H₉ClN₂OS
• Molecular Weight: 312.779
• Mol file: 349643-61-4.mol

Synonyms:3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide

Chemical Property of 3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide

There total 1 articles about 3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-chlorobenzo[b]thiophen-2-carbonyl chloride (21815-91-8) + 4-Aminobenzonitrile (873-74-5) → 3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide (349643-61-4)

Guidance literature:

With triethylamine; In toluene; for 4h; Heating;

DOI:10.1021/jm049541f

Reference yield: 61.0%

3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide (349643-61-4) + ethylenediamine (107-15-3,85404-18-8) → C18H14ClN3OS*ClH (1381771-43-2)

Guidance literature:

3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide; With hydrogenchloride; In ethanol; at 20 ℃;

ethylenediamine; In ethanol; for 24h; Reflux;

DOI:10.1021/jm300505h

Reference yield:

3-chloro-benzo[b]thiophene-2-carboxylic acid (4-cyano-phenyl)-amide (349643-61-4) → N-[4'-(N'-isopropylamidino)phenyl]-3-chlorobenzo[b]thiophene-2-carboxamide hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: HCl(gas) / 4 h / 20 °C

2: 0.8 g / ethanol / 17 h / Heating

With hydrogenchloride; In ethanol;

DOI:10.1021/jm049541f

upstream raw materials:

3-chlorobenzo[b]thiophen-2-carbonyl chloride

4-Aminobenzonitrile

Downstream raw materials:

C₁₈H₁₄ClN₃OS*ClH