8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Base Information

Chemical Name:8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline
CAS No.:98510-01-1
Molecular Formula:C₁₉H₁₇F₃N₂O₃
Molecular Weight:378.351
Hs Code.:

8-amino-6-methoxy-4-(methoxymethyl)-5-<m-(trifluoromethyl)phenoxy>quinoline

Synonyms:8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Suppliers and Price of 8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Chemical Property:

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Technology Process of 8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

There total 4 articles about 8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98510-00-0
6-methoxy-4-(methoxymethyl)-8-nitro-5-quinoline

: 98510-01-1
8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Guidance literature:: With hydrogenchloride; tin; tin(ll) chloride; In tetrahydrofuran; ethanol; at 5 - 10 ℃; for 1h;
DOI:10.1021/jm00149a004

Reference yield:

: 82333-37-7
6-methoxy-4-methyl-8-nitro-5-<3-(trifluoromethyl)phenoxy>quinoline

: 98510-01-1
8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / acetic acid, selenium dioxide / dioxane; acetic anhydride / Heating

2: 88 percent / sodium borohydride / tetrahydrofuran; ethanol / 1 h

3: 70 percent / ethyltributylammonium iodide, potassium hydroxide / tetrahydrofuran; H₂O / 23 h

4: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

With hydrogenchloride; potassium hydroxide; tin; sodium tetrahydroborate; selenium(IV) oxide; tributylethylammonium iodide; acetic acid; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetic anhydride;
DOI:10.1021/jm00149a004

Reference yield:

: 98509-96-7
6-methoxy-8-nitro-5-quinoline-4-carboxaldehyde

: 98510-01-1
8-amino-6-methoxy-4-(methoxymethyl)-5-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / sodium borohydride / tetrahydrofuran; ethanol / 1 h

2: 70 percent / ethyltributylammonium iodide, potassium hydroxide / tetrahydrofuran; H₂O / 23 h

3: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

With hydrogenchloride; potassium hydroxide; tin; sodium tetrahydroborate; tributylethylammonium iodide; tin(ll) chloride; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00149a004