(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

Base Information

Chemical Name:(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid
CAS No.:177274-98-5
Molecular Formula:C₂₅H₂₆N₂O₄
Molecular Weight:418.492
Hs Code.:

Synonyms:(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

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Chemical Property of (E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

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Technology Process of (E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

There total 7 articles about (E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 298-12-4
Glyoxilic acid

: 177275-01-3
O-(cyclohexyl-4-(2-quinolinylmethoxy)phenyl)methyl hydroxylamine

: 177274-98-5
(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

Guidance literature:: With acetic acid; In 1,4-dioxane; methanol; water; at 20 ℃; for 8h;
DOI:10.1021/jm9904102

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 177274-98-5
(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / tetrahydrofuran / 12 h / 20 °C

2: 99 percent / Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

3: 86 percent / hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

4: AcOH / dioxane; H₂O; methanol / 8 h / 20 °C

With hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1: Addition / 2: Mitsunobu reaction / 3: Substitution / 4: Condensation;
DOI:10.1021/jm9904102

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 177274-98-5
(E/Z)-(cyclohexyl(4-(2-quinolinylmethoxy)phenyl)methoxyimino)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: 94 percent / tetrahydrofuran / 12 h / 20 °C

3: 99 percent / Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4: 86 percent / hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

5: AcOH / dioxane; H₂O; methanol / 8 h / 20 °C

With potassium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition / 3: Mitsunobu reaction / 4: Substitution / 5: Condensation;
DOI:10.1021/jm9904102