(3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate
• CAS No.: 1018909-97-1
• Molecular Formula: C₃₆H₅₄FN₅O₆
• Molecular Weight: 671.853

Synonyms:(3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

Chemical Property of (3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

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Technology Process of (3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

There total 1 articles about (3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

tert-butyl 3-fluorophenethyl(2'-oxoethyl)carbamate (1018909-89-1) + (3R,4R)-tert-butyl 3-amino-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate (1018909-96-0) → (3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate (1018909-97-1)

Guidance literature:

tert-butyl 3-fluorophenethyl(2'-oxoethyl)carbamate; (3R,4R)-tert-butyl 3-amino-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Molecular sieve; N₂ atmosphere;

With sodium tris(acetoxy)borohydride; at 20 ℃; for 16h; N₂ atmosphere;

DOI:10.1021/ja910228a

Reference yield: 100.0%

(3R,4R)-tert-butyl 3-(2-(tert-butoxycarbonyl(3-fluorophenethyl)amino)ethylamino)-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate (1018909-97-1) → N(1)-[(3'S,4'S)-4'-((6''-amino-4''-methylpyridin-2''-yl)methyl)pyrrolidin-3'-yl]-N(2)-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃; Under argon; Cooling with ice;

DOI:10.1021/ja910228a

upstream raw materials:

tert-butyl 3-fluorophenethyl(2'-oxoethyl)carbamate

(3R,4R)-tert-butyl 3-amino-4-((6-(tert-butoxycarbonylamino)-4-methylpyridin-2-yl)methyl)pyrrolidine-1-carboxylate

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