benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate

Base Information

• Chemical Name: benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate
• CAS No.: 1166835-71-7
• Molecular Formula: C₂₅H₃₆O₅SSi
• Molecular Weight: 476.709
• Mol file: 1166835-71-7.mol

Synonyms:benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate

Chemical Property of benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate

There total 1 articles about benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(tert-butyldimethylsilanyloxy)propionaldehyde (89922-82-7) + benzyl (R)-(+)-(p-tolylsulfinyl)acetate (148871-73-2) → benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate (1166835-71-7)

Guidance literature:

benzyl (R)-(+)-(p-tolylsulfinyl)acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

3-(tert-butyldimethylsilanyloxy)propionaldehyde; In tetrahydrofuran; at -78 ℃; for 2.5h;

DOI:10.1055/s-0028-1088008

Reference yield:

benzyl (Rs)-5-(tert-butyldimethylsiloxy)-3-hydroxy-2-(p-tolylsulfinyl)pentanoate (1166835-71-7) → C18H30O5SSi

Guidance literature:

With 10% palladium on activated carbon; hydrogen; In ethyl acetate; at 25 ℃; for 4h; under 760.051 Torr;

DOI:10.1055/s-0028-1088008

upstream raw materials:

3-(tert-butyldimethylsilanyloxy)propionaldehyde

benzyl (R)-(+)-(p-tolylsulfinyl)acetate

Refernces