tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Base Information

Chemical Name:tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate
CAS No.:1610372-79-6
Molecular Formula:C₃₂H₃₈N₄O₇S
Molecular Weight:622.742
Hs Code.:

Synonyms:tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Suppliers and Price of tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

There total 14 articles about tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1610373-88-0
tert-butyl(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylthio)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

: 1610372-79-6
tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 - -5 ℃; for 1.25h;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1610372-79-6
tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hydroxide; ethylenediaminetetraacetic acid disodium salt dihydrate / water / 5 h / 90 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 20 h / 60 °C / Inert atmosphere

3.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 14 h / 120 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

7.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

8.1: ammonia / dimethyl sulfoxide / 4 h / 60 °C / Sealed tube

9.1: triethylamine / dichloromethane / 16 h / 20 °C

10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.25 h / -10 - -5 °C

With ethylenediaminetetraacetic acid disodium salt dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; ammonia; phosphorus tribromide; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 168015-04-1
2-bromo-6-(hydroxymethyl)pyridin-3-ol

: 1610372-79-6
tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 h / 60 °C / Inert atmosphere

2.1: 2-iodoxybenzoic acid / dimethyl sulfoxide / 3 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 16 h / 90 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 14 h / 120 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6.1: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

7.1: ammonia / dimethyl sulfoxide / 4 h / 60 °C / Sealed tube

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.25 h / -10 - -5 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-iodoxybenzoic acid; tetrabutyl ammonium fluoride; ammonia; phosphorus tribromide; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;