N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1345992-43-9
Molecular Formula:C₂₆H₂₂Cl₄N₄O
Molecular Weight:548.299
Hs Code.:

Synonyms:N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

There total 8 articles about N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1345992-78-0
1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydro-2H-isoindol-2-yl)-1H-pyrazole-3-carboxylic acid

: 102-49-8
3,4-dichlorobenzyl amine

: 1345992-43-9
N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.09.037

Reference yield:

: 1015765-46-4
ethyl 5-amino-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate

: 1345992-43-9
N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1 h / 110 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

2.2: pH 2

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.09.037

Reference yield:

: 3971-29-7,25712-33-8
1,2-bis(hydroxymethyl)cyclohexane

: 1345992-43-9
N-(3,4-dichlorobenzyl)-1-(2,4-dichlorophenyl)-4-methyl-5-(4,5,6,7-tetrahydroisoindol-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: acetic acid / 1 h / 110 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.2: pH 2

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With oxalyl dichloride; benzotriazol-1-ol; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; 1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1016/j.ejmech.2011.09.037