(R)-2-hydroxybutanamide

Base Information

• Chemical Name: (R)-2-hydroxybutanamide
• CAS No.: 206358-12-5
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.121
• Mol file: 206358-12-5.mol

Synonyms:Butanamide,2-hydroxy-, (R)-

Chemical Property of (R)-2-hydroxybutanamide

Chemical Property:

• PSA: 63.32000
• LogP: -0.05710

Purity/Quality:

99% ^*data from raw suppliers

2-hydroxybutanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-hydroxybutanamide

There total 12 articles about (R)-2-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-hydroxybutanenitrile (4476-02-2) → beta-hydroxybutyramide (1113-58-2,206358-12-5)

Guidance literature:

With [RuCl₂(η³:η³-C₁₀H₁₆){PMe₂(OH)}]; water; at 20 ℃; for 72h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c4cc04058a

Reference yield: 47.0%

C6H11NO3(2-)*2Br(1-)*2Mg(2+) → beta-hydroxybutyramide (1113-58-2,206358-12-5)

Guidance literature:

In toluene; at 110 - 114 ℃; for 6h;

Reference yield:

crotonamide (625-37-6) → (Z)-but-2-enamide (31110-30-2) + beta-hydroxybutyramide (1113-58-2,206358-12-5)

Guidance literature:

With acetic acid; lithium iodide; In [D₃]acetonitrile; at 20 ℃; for 3h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.joc.8b02162

upstream raw materials:

methyl (S)-2-hydroxybutyrate

2-Bromobutyric acid

formamide

2-hydroxybutanenitrile