1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

Base Information

Chemical Name:1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene
CAS No.:308255-25-6
Molecular Formula:C₃₂H₂₈F₆OS₂
Molecular Weight:606.696
Hs Code.:

Synonyms:1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

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Chemical Property of 1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

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Technology Process of 1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

There total 5 articles about 1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 35026-81-4
(2S)-methylbuthyl-1-magnesium bromide

: 295343-51-0
3-(2-(2-methyl-5-phenylthiophen-3-yl)perfluorocyclopent-1-en-1-yl)-5-phenylthiophene-2-carbaldehyde

: 308255-25-6
1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja001350o

Reference yield:

: 23688-07-5
3,5-dibromo-2-thiophenecarboxaldehyde

: 308255-25-6
1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / p-TsOH*H₂O / benzene / 13 h / Heating

2.1: 55 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 7 h / Heating

3.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

3.2: 43 percent / tetrahydrofuran / 5 h / -78 °C

4.1: 95 percent / pyridinium tosylate / acetone / 12 h / Heating

5.1: 50 percent / tetrahydrofuran / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; acetone; benzene; 5.1: Grignard reaction;
DOI:10.1021/ja001350o

Reference yield:

: 286958-92-7
3,5-dibromo-2-(1,3-dioxolan-2-yl)-thiophene

: 308255-25-6
1-(2-methyl-5-phenyl-3-thienyl)-2-[2-(3-methyl-1-hydroxy-1-pentyl)-5-phenyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopentene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 55 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 7 h / Heating

2.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

2.2: 43 percent / tetrahydrofuran / 5 h / -78 °C

3.1: 95 percent / pyridinium tosylate / acetone / 12 h / Heating

4.1: 50 percent / tetrahydrofuran / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; pyridinium p-toluenesulfonate; sodium carbonate; In tetrahydrofuran; acetone; 4.1: Grignard reaction;
DOI:10.1021/ja001350o