(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

Base Information

Chemical Name:(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile
CAS No.:1609623-77-9
Molecular Formula:C₂₄H₂₄N₂O₂
Molecular Weight:372.467
Hs Code.:

Synonyms:(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

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Chemical Property of (3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

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Technology Process of (3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

There total 6 articles about (3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (E)-N-benzyl-2-cyano-3-phenylacrylamide

: 17424-21-4
5-methyl-hexadien-trans-2,4-al

: 1609623-77-9
(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

: C₂₄H₂₄N₂O₂

Guidance literature:: With (L)-2-{diphenyl[(triphenylsilyl)oxy]methyl}pyrrolidine; 4-nitro-benzoic acid; In 1,4-dioxane; at 70 ℃; Reagent/catalyst; stereoselective reaction;
DOI:10.1039/c4cc01231c

Reference yield: 49.0%

: (E)-N-benzyl-2-cyano-3-phenylacrylamide

: 17424-21-4
5-methyl-hexadien-trans-2,4-al

: 1609623-77-9
(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

: C₂₄H₂₄N₂O₂

: (3R,4aR,8S,8aR)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

Guidance literature:: With (-)-(S)-α,α-diphenylpyrrolidine-2-methanol methyl(diphenyl)silyl ether; 4-nitro-benzoic acid; In 1,4-dioxane; at 70 ℃; Reagent/catalyst; stereoselective reaction;
DOI:10.1039/c4cc01231c

Reference yield:

: 10412-93-8
N-Benzylcyanoacetamide

: 1609623-77-9
(3S,4aS,8R,8aS)-2-benzyl-3-hydroxy-6-methyl-1-oxo-8-phenyl-2,3,4,4a,7,8-hexahydroisoquinoline-8a(1H)-carbonitrile

: C₂₄H₂₄N₂O₂

Guidance literature:: Multi-step reaction with 2 steps

1: pyrrolidine / ethanol / 1 h / 20 °C

2: 4-nitro-benzoic acid; (L)-2-{diphenyl[(triphenylsilyl)oxy]methyl}pyrrolidine / 1,4-dioxane / 70 °C

With pyrrolidine; (L)-2-{diphenyl[(triphenylsilyl)oxy]methyl}pyrrolidine; 4-nitro-benzoic acid; In 1,4-dioxane; ethanol;
DOI:10.1039/c4cc01231c