Technology Process of N-p-toluenesulfonyl-1,3-dimethyl-2-azaadamantane
There total 11 articles about N-p-toluenesulfonyl-1,3-dimethyl-2-azaadamantane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium iodide;
In
isopropyl alcohol;
Heating;
DOI:10.1021/ja0620336
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: 81 percent / p-TsCl / pyridine; benzene / 12 h / 75 °C
2.1: 100 percent / H2 / Pd/C / methanol / 3 h / 20 °C
3.1: aq. NH3 / 0.17 h / 20 °C
3.2: 89 percent / 37 h / 50 °C
4.1: 100 percent / TfOH / CH2Cl2 / 2 h / 0 °C
5.1: 98 percent / DMAP; Et3N / CH2Cl2 / 0.17 h / 0 °C
6.1: aq. KOH / ethanol / 15 h / Heating
7.1: 156 mg / AcCl / 5 h / 80 °C
8.1: 40 percent / pyridine / 19 h / Heating
9.1: 82 percent / DIBAL / toluene / 0.5 h / 0 °C
10.1: 77 percent / PPh3; imidazole; I2 / CH2Cl2 / 2 h / 20 °C
11.1: 65 percent / NaI / propan-2-ol / Heating
With
pyridine; 1H-imidazole; dmap; potassium hydroxide; ammonium hydroxide; trifluorormethanesulfonic acid; hydrogen; iodine; diisobutylaluminium hydride; triethylamine; acetyl chloride; p-toluenesulfonyl chloride; triphenylphosphine; sodium iodide;
palladium on activated charcoal;
In
pyridine; methanol; ethanol; dichloromethane; isopropyl alcohol; toluene; benzene;
DOI:10.1021/ja0620336
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 100 percent / H2 / Pd/C / methanol / 3 h / 20 °C
2.1: aq. NH3 / 0.17 h / 20 °C
2.2: 89 percent / 37 h / 50 °C
3.1: 100 percent / TfOH / CH2Cl2 / 2 h / 0 °C
4.1: 98 percent / DMAP; Et3N / CH2Cl2 / 0.17 h / 0 °C
5.1: aq. KOH / ethanol / 15 h / Heating
6.1: 156 mg / AcCl / 5 h / 80 °C
7.1: 40 percent / pyridine / 19 h / Heating
8.1: 82 percent / DIBAL / toluene / 0.5 h / 0 °C
9.1: 77 percent / PPh3; imidazole; I2 / CH2Cl2 / 2 h / 20 °C
10.1: 65 percent / NaI / propan-2-ol / Heating
With
pyridine; 1H-imidazole; dmap; potassium hydroxide; ammonium hydroxide; trifluorormethanesulfonic acid; hydrogen; iodine; diisobutylaluminium hydride; triethylamine; acetyl chloride; triphenylphosphine; sodium iodide;
palladium on activated charcoal;
In
methanol; ethanol; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1021/ja0620336
