N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide

Base Information

• Chemical Name: N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide
• CAS No.: 1403990-50-0
• Molecular Formula: C₂₁H₁₃F₃N₄O₂
• Molecular Weight: 410.355

Synonyms:N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide

Chemical Property of N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide

Chemical Property:

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Technology Process of N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide

There total 2 articles about N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one (1316792-97-8) + trifluoroacetic anhydride (407-25-0) → N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide (1403990-50-0)

Guidance literature:

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

trifluoroacetic anhydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 12h;

DOI:10.1021/ol302714j

Reference yield:

1,3-diphenylbenzo[e]-[1,2,4]triazin-7(1H)-one (22751-79-7) → N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide (1403990-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O-benzylhydoxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 20 - 78 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

2.2: 12 h / 20 °C

With O-benzylhydoxylamine hydrochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ol302714j

Reference yield: 80.0%

N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)trifluoroacetamide (1403990-50-0) → 1,3-diphenyl-7-trifluoromethyl-1,4-dihydrothiazolo[5',4':4,5]benzo[1,2-e][1,2,4]triazin-4-yl (1403990-57-7)

Guidance literature:

With tetraphosphorus decasulfide; In toluene; at 110 ℃; for 1h;

DOI:10.1021/ol302714j

upstream raw materials:

6-amino-1,3-diphenylbenzo[e][1,2,4]triazin-7-(1H)-one

trifluoroacetic anhydride

1,3-diphenylbenzo[e]-[1,2,4]triazin-7(1H)-one

Downstream raw materials:

1,3-diphenyl-7-trifluoromethyl-1,4-dihydrothiazolo[5',4':4,5]benzo[1,2-e][1,2,4]triazin-4-yl

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