Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn

Base Information

• Chemical Name: Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn
• CAS No.: 855258-95-6
• Molecular Formula: C₄₂H₆₆N₆O₁₅S₂
• Molecular Weight: 959.149
• Mol file: 855258-95-6.mol

Synonyms:Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn

Chemical Property of Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn

There total 1 articles about Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetylamino-4-[({5-tert-butoxycarbonylamino-1-[1-(carboxymethyl-carbamoyl)-2-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylsulfanyl)-ethylcarbamoyl]-pentylcarbamoyl}-methyl)-carbamoyl]-butyric acid tert-butyl ester + phenylmethanethiol (100-53-8) → Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn (855258-95-6)

Guidance literature:

With 1-hydroxybenzylthiol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 24h;

DOI:10.1021/ja050304r

Reference yield: 88.0%

Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn (855258-95-6) → Ac-Glu-Gly-Lys-Cys(Glcβ1)-Gly-SBn (855259-86-8)

Guidance literature:

With chlorotriisopropylsilane; ethane-1,2-dithiol; trifluoroacetic acid; In dichloromethane; at 23 ℃; for 1.5h;

DOI:10.1021/ja050304r

Reference yield:

Ac-Glu(t-Bu)-Gly-Lys(Boc)-Cys(Glcβ1)-Gly-SBn (855258-95-6) → Ac-Glu-Gly-Lys-Cys(Glcβ1)-Gly-Cys-Ala-Ser-Phe-Asp-OH

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / TFA; (i-Pr)3SiH; HS(CH₂)2SH / CH₂Cl₂ / 1.5 h / 23 °C

2: 83 percent / guanidine hydrochloride; PhSH / aq. phosphate buffer / 28 h / 23 °C / pH 7.5

With chlorotriisopropylsilane; guanidine hydrochloride; ethane-1,2-dithiol; thiophenol; trifluoroacetic acid; In phosphate buffer; dichloromethane;

DOI:10.1021/ja050304r

upstream raw materials:

phenylmethanethiol

Downstream raw materials:

Ac-Glu-Gly-Lys-Cys(Glcβ1)-Gly-SBn