2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester

Base Information

• Chemical Name: 2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester
• CAS No.: 627874-20-8
• Molecular Formula: C₃₆H₃₈N₆O₈
• Molecular Weight: 682.733

Synonyms:2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester

Chemical Property of 2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester

There total 1 articles about 2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride (59157-06-1) + L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) → 2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester (627874-20-8)

Guidance literature:

With N,N-diethylaniline; In dichloromethane; at -78 - 20 ℃; for 1.5h;

DOI:10.3390/molecules13123149

Reference yield: 73.0%

2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester (627874-20-8) + 1,6-Hexanediamine (124-09-4) → 2-{[5-(6-{[5-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-3H-imidazole-4-carbonyl]-amino}-hexylcarbamoyl)-1H-imidazole-4-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo049045z

Reference yield: 65.0%

2-{[6-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)-5,10-dioxo-5H,10H-diimidazo[1,5-a;1',5'-d]pyrazine-1-carbonyl]-amino}-3-phenyl-propionic acid tert-butyl ester (627874-20-8) + C2HF3O2*C14H22N2O2 (1217317-64-0) → C32H41N5O6 (1217318-02-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1021/cc1000105

upstream raw materials:

4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride

L-phenylalanine tert-butyl ester hydrochloride

Downstream raw materials:

C₂₉H₃₅N₅O₆

C₃₂H₄₁N₅O₆

C₂₈H₃₃N₅O₆

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