trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

Base Information

Chemical Name:trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde
CAS No.:123169-47-1
Molecular Formula:C₂₅H₂₈N₂O₅S
Molecular Weight:468.574
Hs Code.:

Synonyms:trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

Chemical Property:

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Technology Process of trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

There total 5 articles about trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 123169-46-0
trans-5-ethyl-2-<1-(phenylsulfonyl)-2-indolyl>-1-(2-hydroxyethyl)-4-piperidone ethylene acetal

: 123169-47-1
trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -70 ℃; for 1h;
DOI:10.1021/jo00284a037

Reference yield:

: 123169-45-9,132241-97-5
trans-5-ethyl-2-<1-(phenylsulfonyl)-2-indolyl>-4-piperidone ethylene acetal

: 123169-47-1
trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Na₂CO₃ / ethanol / 15 h / Heating

2: 92 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -70 °C

With oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; In ethanol; dichloromethane;
DOI:10.1021/jo00284a037

Reference yield:

: 123169-44-8
2-ethyl-3,3-(ethylenedioxy)-N-<<1-(phenylsulfonyl)-2-indolyl>methylene>butylamine

: 123169-47-1
trans-5-ethyl-4,4-(ethylenedioxy)-2-<1-(phenylsulfonyl)-2-indolyl>-1-piperidineacetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / p-TsOH / benzene / 1 h / Heating

2: 85 percent / Na₂CO₃ / ethanol / 15 h / Heating

3: 92 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -70 °C

With oxalyl dichloride; sodium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; In ethanol; dichloromethane; benzene;
DOI:10.1021/jo00284a037