(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

Base Information

Chemical Name:(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane
CAS No.:804561-30-6
Molecular Formula:C₁₉H₂₇ClO₂
Molecular Weight:322.875
Hs Code.:

Synonyms:(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

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Chemical Property of (2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

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Technology Process of (2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

There total 5 articles about (2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51699-45-7
(S)-(-)-1-(3'-Chlorophenyl)-1,3-Propanediol

: 804561-30-6
(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / trimethylsilyl triflate / tetrahydrofuran / 1 h / 20 °C

2: 7.50 g / trimethylsilyltriflate / CH₂Cl₂ / 48 h / -50 °C

With trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja031818y

Reference yield:

: 51699-40-2,138307-15-0
3-(3-chlorophenyl)-3-hydroxypropionic acid ethyl ester

: 804561-30-6
(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 3 steps

1: 24 g / LiAlH₄ / diethyl ether

2: 100 percent / trimethylsilyl triflate / tetrahydrofuran / 1 h / 20 °C

3: 7.50 g / trimethylsilyltriflate / CH₂Cl₂ / 48 h / -50 °C

With lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja031818y

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 804561-30-6
(2S,8R,11S)-2-(3-chlorophenyl)-8-methyl-11-(1-methylethyl)-1,5-dioxaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; acetonitrile / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 24 g / LiAlH₄ / diethyl ether

3.1: 100 percent / trimethylsilyl triflate / tetrahydrofuran / 1 h / 20 °C

4.1: 7.50 g / trimethylsilyltriflate / CH₂Cl₂ / 48 h / -50 °C

With lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ja031818y