[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Base Information

Chemical Name:[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol
CAS No.:871838-10-7
Molecular Formula:C₂₉H₃₈N₂O₂
Molecular Weight:446.633
Hs Code.:

Synonyms:[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Suppliers and Price of [6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

There total 13 articles about [6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 871838-05-0
6'-(3-benzyloxy-propyl)-6,2'-diisobutyl[2,3']bipyridinyl-5-carboxylic acid ethyl ester

: 871838-10-7
[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/ol0521228

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 871838-10-7
[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 54 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

2.1: 79 percent / CrO₃; H₂SO₄ / acetone; H₂O / 0.67 h / 0 °C

3.1: ammonium acetate / toluene / 1 h / Heating

3.2: 65 percent / ytterbium(III) triflate / toluene / 48 h / Heating

4.1: 82 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

5.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.42 h / -78 - 0 °C

6.1: 89 percent / tetrahydrofuran / -78 - 0 °C

7.1: 89 percent / MnO₂ / CH₂Cl₂ / 3 h / 20 °C

8.1: ammonium acetate / toluene / 1 h / Heating

8.2: 78 percent / ytterbium(III) triflate / toluene / 48 h / Heating

9.1: 78 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

With chromium(VI) oxide; ammonium acetate; manganese(IV) oxide; oxalyl dichloride; sulfuric acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; toluene; 2.1: Jones oxidation / 3.2: Bohlmann-Rahtz heteroannulation / 5.1: Swern oxidation / 8.2: Bohlmann-Rahtz heteroannulation;
DOI:10.1021/ol0521228

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 871838-10-7
[6'-(3-benzyloxy-propyl)-6,2'-diisobutyl-[2,3']bipyridinyl-5-yl]-methanol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 89 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 0.75 h / -78 - 0 °C

2.1: 54 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

3.1: 79 percent / CrO₃; H₂SO₄ / acetone; H₂O / 0.67 h / 0 °C

4.1: ammonium acetate / toluene / 1 h / Heating

4.2: 65 percent / ytterbium(III) triflate / toluene / 48 h / Heating

5.1: 82 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

6.1: 90 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.42 h / -78 - 0 °C

7.1: 89 percent / tetrahydrofuran / -78 - 0 °C

8.1: 89 percent / MnO₂ / CH₂Cl₂ / 3 h / 20 °C

9.1: ammonium acetate / toluene / 1 h / Heating

9.2: 78 percent / ytterbium(III) triflate / toluene / 48 h / Heating

10.1: 78 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

With chromium(VI) oxide; ammonium acetate; manganese(IV) oxide; oxalyl dichloride; sulfuric acid; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone; toluene; 1.1: Swern oxidation / 3.1: Jones oxidation / 4.2: Bohlmann-Rahtz heteroannulation / 6.1: Swern oxidation / 9.2: Bohlmann-Rahtz heteroannulation;
DOI:10.1021/ol0521228