benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride

Base Information

• Chemical Name: benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride
• CAS No.: 1460305-70-7
• Molecular Formula: C₂₈H₂₈F₃N₅O₆*ClH
• Molecular Weight: 624.016

Synonyms:benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride

Chemical Property of benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride

There total 10 articles about benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

benzyl(16S,18S)-16-[(tert-butoxycarbonyl)amino]-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.02'6.014'18]pentacosa-1(25),2(6),3,21,23-pentaene-11-carboxylate (1460305-68-3) → benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.02,6.014,18]pentacosa-1(25),2(6),3,21,23-pentaene-11-carboxylate hydrochloride (1460305-70-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1.5h;

Reference yield:

C14H12F3NO4 (1460306-56-2) → benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.02,6.014,18]pentacosa-1(25),2(6),3,21,23-pentaene-11-carboxylate hydrochloride (1460305-70-7)

Guidance literature:

Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 - 20 °C

3: toluene / 1.5 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane; ethyl acetate / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 2 h

6: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; boron tribromide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl 3-amino-3-(3-methoxyphenyl)-2-propenoate → benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.02,6.014,18]pentacosa-1(25),2(6),3,21,23-pentaene-11-carboxylate hydrochloride (1460305-70-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 1,2-dichloro-ethane / 16 h / 45 °C

2: boron tribromide / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 - 20 °C

4: toluene / 1.5 h / Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane; ethyl acetate / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 2 h

7: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; boron tribromide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-(3-hydroxyphenyl)-2-(trifluoromethyl)oxazole-5-carboxylic acid

C₁₄H₁₂F₃NO₄

C₂₆H₂₄F₃N₃O₇

benzyl(16S,18S)-16-[(tert-butoxycarbonyl)amino]-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0²'⁶.0¹⁴'¹⁸]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1460305-70-7 benzyl (16S,18S)-16-amino-7,13-dioxo-4-(trifluoromethyl)-5,20-dioxa-3,8,11,14-tetraazatetracyclo[19.3.1.0^2,6.0^14,18]pentacosa-1⁽²⁵⁾,2⁽⁶⁾,3,21,23-pentaene-11-carboxylate hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send