N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

Base Information

Chemical Name:N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide
CAS No.:75971-30-1
Molecular Formula:C₃₁H₃₆FN₅O₂
Molecular Weight:529.658
Hs Code.:

Synonyms:N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

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Chemical Property of N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

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Technology Process of N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

There total 9 articles about N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 105-35-1
2-chloro-N-ethylacetamide

: 73736-50-2
O-desmethyl astemizole

: 75971-30-1
N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

Guidance literature:: With potassium carbonate; In acetone;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 75971-30-1
N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

4: 88.5 percent / H₂ / 10 percent Pd/C / methanol

5: 19 percent / K₂CO₃ / acetone

With hydrogen bromide; hydrogen; sodium carbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 75971-30-1
N-Ethyl-2-[4-(2-{4-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

3: 88.5 percent / H₂ / 10 percent Pd/C / methanol

4: 19 percent / K₂CO₃ / acetone

With hydrogen bromide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00150a029