iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile

Base Information

• Chemical Name: iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile
• CAS No.: 845749-64-6
• Molecular Formula: C₁₂H₁₁IN₂O₂
• Molecular Weight: 342.136
• Mol file: 845749-64-6.mol

Synonyms:iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile

Chemical Property of iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile

There total 2 articles about iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

hydroxy-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile (845749-47-5) → iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile (845749-64-6)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; at 20 ℃;

Reference yield:

(RS)-1-(4-methoxyphenyl)-4-oxoazetidine-2-carbaldehyde (180629-31-6) → iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile (845749-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / AcOH / acetonitrile; H₂O / 1 h / 20 °C

2: 44 percent / I₂; Ph₃P; imidazole / 20 °C

With 1H-imidazole; iodine; acetic acid; triphenylphosphine; In water; acetonitrile;

Reference yield: 83.0%

iodo-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile (845749-64-6) → (+/-)-4-cyanomethyl-1-(4-methoxyphenyl)azetidin-2-one (145887-50-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 0.25h; Heating;

upstream raw materials:

hydroxy-[1-(4-methoxyphenyl)-4-oxo-azetidin-2-yl]acetonitrile

(RS)-1-(4-methoxyphenyl)-4-oxoazetidine-2-carbaldehyde

Downstream raw materials:

(+/-)-4-cyanomethyl-1-(4-methoxyphenyl)azetidin-2-one