3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Base Information

Chemical Name:3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one
CAS No.:1384262-88-7
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Chemical Property of 3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

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Technology Process of 3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

There total 3 articles about 3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1384262-87-6
6-(4-methoxybenzyl)-3-vinyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one

: 1384262-88-7
3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: 6-(4-methoxybenzyl)-3-vinyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one; With ozone; In methanol; dichloromethane; for 0.333333h; Cooling with acetone-dry ice;

With sodium tetrahydroborate; In methanol; dichloromethane;

Reference yield:

: 1384262-86-5
methyl 2,5-divinylnicotinate

: 1384262-88-7
3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 0.33 h / 150 °C / Microwave reactor

2: ozone / dichloromethane; methanol / 0.33 h / Cooling with acetone-dry ice

With ozone; In methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 29241-65-4
5-bromo-2-chloronicotinic acid

: 1384262-88-7
3-(hydroxymethyl)-6-(4-methoxybenzyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 36 h / 60 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 110 °C

2.2: 0.5 h

3.1: N,N-dimethyl acetamide / 0.33 h / 150 °C / Microwave reactor

4.1: ozone / dichloromethane; methanol / 0.33 h / Cooling with acetone-dry ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ozone; In methanol; dichloromethane; N,N-dimethyl acetamide; toluene;