4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide

Base Information

• Chemical Name: 4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide
• CAS No.: 1236266-04-8
• Molecular Formula: C₂₂H₂₃ClN₄O
• Molecular Weight: 394.904

Synonyms:4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide

Chemical Property of 4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide

Chemical Property:

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Technology Process of 4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide

There total 1 articles about 4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dichloro-2-methylpyrimidine (1780-26-3) + 4-(aminomethyl)-N-ethyl-N-m-tolylbenzamide TFA salt (1236265-84-1) → 4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide (1236266-04-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide (1236266-04-8) + 1,2,3,4-tetrahydroisoquinoline (14099-81-1) → 4-((6-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236265-15-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 115 ℃;

Reference yield:

4-((6-chloro-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-mtolylbenzamide (1236266-04-8) + 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride (2328-12-3) → 4-((6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide (1236265-18-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 115 ℃;

upstream raw materials:

2,4-dichloro-2-methylpyrimidine

4-(aminomethyl)-N-ethyl-N-m-tolylbenzamide TFA salt

Downstream raw materials:

4-((6-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

4-((6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpyrimidin-4-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

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