5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

Base Information

Chemical Name:5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one
CAS No.:881424-71-1
Molecular Formula:C₁₇H₂₀BrNO
Molecular Weight:334.256
Hs Code.:

Synonyms:5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

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Chemical Property of 5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

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Technology Process of 5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

There total 4 articles about 5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 881424-70-0
{2-[1-(4-bromophenyl)-2-methylcarbamoylethyl]-cyclohexylidenemethyl}-(4-methoxyphenyl)-carbamic acid tert-butyl ester

: 881424-71-1
5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

Guidance literature:: With hydrogenchloride; In chloroform; for 3h;
DOI:10.1021/ja057592b

Reference yield:

: 862121-72-0
cyclohex-1-enylmethyl-(4-methoxyphenyl)carbamic acid tert-butyl ester

: 881424-71-1
5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (-)-sparteine; n-BuLi / toluene / 1 h / -78 °C

1.2: toluene / 3 h / -78 °C

2.1: Me₃Al / CH₂Cl₂; hexane; tetrahydrofuran / 0.25 h

2.2: 81 percent / CH₂Cl₂; hexane; tetrahydrofuran / 40 h / 40 °C

3.1: 72 percent / aq. HCl / CHCl₃ / 3 h

With hydrogenchloride; n-butyllithium; trimethylaluminum; (-)-sparteine; In tetrahydrofuran; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/ja057592b

Reference yield:

: 862122-12-1
3-(4-bromophenyl)-3-(2-{[tert-butoxycarbonyl-(4-methoxyphenyl)amino]-methylene}cyclohexyl)propionic acid ethyl ester

: 881424-71-1
5-(4-bromophenyl)-2-methyl-2,4,5,5a,6,7,8,9-octahydrobenzo[c]azepin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃Al / CH₂Cl₂; hexane; tetrahydrofuran / 0.25 h

1.2: 81 percent / CH₂Cl₂; hexane; tetrahydrofuran / 40 h / 40 °C

2.1: 72 percent / aq. HCl / CHCl₃ / 3 h

With hydrogenchloride; trimethylaluminum; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/ja057592b