N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

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Chemical Name:N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide
CAS No.:1253383-72-0
Molecular Formula:C₂₄H₂₇ClN₆O₄S
Molecular Weight:531.035
Hs Code.:

Synonyms:N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

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Chemical Property of N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

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Technology Process of N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

There total 4 articles about N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1253383-66-2
1-[4-(3-amino-5-chloro-pyridin-2-yl)-piperazin-1-yl]-2-(3,5-dimethyl-pyrazol-1-yl)-ethanone

: 4052-30-6
4-methylsulfonylbenzoic acid

: 1253383-72-0
N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

Guidance literature:: 4-methylsulfonylbenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;

1-[4-(3-amino-5-chloro-pyridin-2-yl)-piperazin-1-yl]-2-(3,5-dimethyl-pyrazol-1-yl)-ethanone; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 1-(5-chloro-3-nitro-pyridin-2-yl)-piperazine hydrochloride

: 1253383-72-0
N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: hydrogen / sulfided platinum on carbon / methanol; ethyl acetate / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 72 h / 20 °C / Inert atmosphere

With oxalyl dichloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sulfided platinum on carbon; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 16034-49-4
2-(3,5-dimethyl-1H-pyrazol-1-yl)acetic acid

: 1253383-72-0
N-(5-chloro-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)-acetyl]-piperazin-1-yl}-pyridin-3-yl)-4-methanesulfonyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: hydrogen / sulfided platinum on carbon / methanol; ethyl acetate / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 72 h / 20 °C / Inert atmosphere

With oxalyl dichloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sulfided platinum on carbon; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;