(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Base Information

Chemical Name:(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide
CAS No.:1620291-75-9
Molecular Formula:C₂₂H₂₀N₆O₃
Molecular Weight:416.439
Hs Code.:

Synonyms:(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

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Chemical Property of (R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

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Technology Process of (R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

There total 5 articles about (R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620291-74-8
N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-75-9
(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-76-0
(S)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: With CHIRAL PAK AD-H; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 1620293-32-4
2-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)isoindoline-1,3-dione

: 1620291-75-9
(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-76-0
(S)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol / 3 h / 60 °C

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: CHIRAL PAK AD-H / ethanol; hexane / Resolution of racemate

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1620293-34-6
(5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride

: 1620291-75-9
(R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

: 1620291-76-0
(S)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

2: CHIRAL PAK AD-H / ethanol; hexane / Resolution of racemate

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In ethanol; hexane; N,N-dimethyl-formamide;