methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne

Base Information

• Chemical Name: methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne
• CAS No.: 129055-65-8
• Molecular Formula: C₁₄H₂₀O₂
• Molecular Weight: 220.312
• Mol file: 129055-65-8.mol

Synonyms:methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne

Chemical Property of methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne

There total 2 articles about methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5,6-epoxy-6-methyl-2-heptanone (16262-93-4) + phenylmagnesium bromide → methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne (129055-65-8)

Guidance literature:

In tetrahydrofuran; for 12h; Ambient temperature;

DOI:10.1016/S0022-328X(00)83466-X

Reference yield: 70.0%

5,6-epoxy-6-methyl-2-heptanone (16262-93-4) + phenyllithium (591-51-5) → methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne (129055-65-8)

Guidance literature:

In diethyl ether; for 12h; Ambient temperature;

DOI:10.1016/S0022-328X(00)83466-X

Reference yield: 82.0%

methyl-2 phenyl-2 (methyl-1 hydroxy-1 ethyl)-5 tetrahydrofuranne (129055-65-8) → 5-methyl-5-phenyl-dihydro-furan-2-one (7210-42-6,21303-80-0,69854-29-1,88314-79-8)

Guidance literature:

With 3 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 3.5h; Heating;

DOI:10.1016/S0040-4039(00)94696-3

upstream raw materials:

5,6-epoxy-6-methyl-2-heptanone

phenyllithium

Downstream raw materials:

5-methyl-5-phenyl-dihydro-furan-2-one