Technology Process of 3-(3-(4-((bis(tert-butyl)phosphono)methyl)phenyl)propanoyl)-4(S)-benzyl-1,3-oxazolidin-2-one
There total 6 articles about 3-(3-(4-((bis(tert-butyl)phosphono)methyl)phenyl)propanoyl)-4(S)-benzyl-1,3-oxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium;
In
ethanol;
under 2068.65 Torr;
DOI:10.1021/jo000643x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NMM; pivaloyl chloride / tetrahydrofuran / 1 h / -78 °C
1.2: 49 percent / Evan's reagent; n-BuLi / tetrahydrofuran; hexane / 1.5 h / -78 °C
2.1: 79 percent / P(o-tolyl)3; Et3N / Pd(OAc)2 / 85 °C
3.1: 82 percent / H2 / Pd black / ethanol / 2068.65 Torr
With
4-methyl-morpholine; hydrogen; pivaloyl chloride; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate; palladium;
In
tetrahydrofuran; ethanol;
1.1: Dehydration / 1.2: Acylation / 2.1: Heck coupling / 3.1: Hydrogenation;
DOI:10.1021/jo000643x
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
2: 79 percent / P(o-tolyl)3; Et3N / Pd(OAc)2 / 85 °C
3: 82 percent / H2 / Pd black / ethanol / 2068.65 Torr
With
n-butyllithium; hydrogen; triethylamine; tris-(o-tolyl)phosphine;
palladium diacetate; palladium;
In
tetrahydrofuran; ethanol; hexane;
1: Alkylation / 2: Heck coupling / 3: Hydrogenation;
DOI:10.1021/jo000643x
