[7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine

Base Information

• Chemical Name: [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine
• CAS No.: 886599-17-3
• Molecular Formula: C₁₄H₁₅N₅O
• Molecular Weight: 269.306

Synonyms:[7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine

Chemical Property of [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine

Chemical Property:

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Technology Process of [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine

There total 6 articles about [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-chloro-7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (886599-12-8) → [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine (886599-17-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃;

DOI:10.1016/j.bmcl.2006.01.057

Reference yield:

3-amino-4-(3-methoxy-phenyl)-1H-pyrrole-2-carbonitrile (886599-16-2) → [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine (886599-17-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / Heating

2: 100 percent / POCl₃

3: 75 percent / K₂CO₃

4: 82 percent / hydrazine hydrate / ethanol / 80 °C

With potassium carbonate; hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2006.01.057

Reference yield:

7-(3-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol (886599-18-4) → [7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl]-hydrazine (886599-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / POCl₃

2: 75 percent / K₂CO₃

3: 82 percent / hydrazine hydrate / ethanol / 80 °C

With potassium carbonate; hydrazine hydrate; trichlorophosphate; In ethanol;

DOI:10.1016/j.bmcl.2006.01.057

upstream raw materials:

4-chloro-7-(3-methoxy-phenyl)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine

3-amino-4-(3-methoxy-phenyl)-1H-pyrrole-2-carbonitrile

4-chloro-7-(3-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine

7-(3-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol

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