(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

Base Information

Chemical Name:(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate
CAS No.:1338789-80-2
Molecular Formula:C₄₅H₃₈N₃O₁₅P
Molecular Weight:891.782
Hs Code.:

Synonyms:(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

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Chemical Property of (S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

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Technology Process of (S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

There total 9 articles about (S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1338789-78-8
(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)-phosphoryloxy)-8-formyl-2-oxo-2H-chromen-4-yl)propanoate

: 1338789-80-2
(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

Guidance literature:: With sodium tetrahydroborate; In ethanol; dichloromethane; at 0 ℃; for 0.0833333h;
DOI:10.1039/c1cc14653j

Reference yield:

: 1338789-74-4
(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-hydroxy-2-oxo-2H-chromen-4-yl)propanoate

: 1338789-80-2
(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 3 h / 100 - 150 °C

1.2: 1 h

2.1: dmap; triethylamine / dichloromethane / 5 h / Cooling with ice

3.1: sodium tetrahydroborate / ethanol; dichloromethane / 0.08 h / 0 °C

With dmap; sodium tetrahydroborate; acetic acid; triethylamine; In ethanol; dichloromethane; 1.1: Duff reaction / 1.2: Duff reaction;
DOI:10.1039/c1cc14653j

Reference yield:

: 1338789-72-2
(S)-allyl 6-methyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-oxohexanedioate

: 1338789-80-2
(S)-allyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(7-(bis(2-nitrobenzyloxy)phosphoryloxy)-8-(hydroxymethyl)-2-oxo-2H-chromen-4-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid / 4 h / 4 °C / Cooling with ice

2.1: acetic acid / 3 h / 100 - 150 °C

2.2: 1 h

3.1: dmap; triethylamine / dichloromethane / 5 h / Cooling with ice

4.1: sodium tetrahydroborate / ethanol; dichloromethane / 0.08 h / 0 °C

With dmap; sodium tetrahydroborate; methanesulfonic acid; acetic acid; triethylamine; In ethanol; dichloromethane; 2.1: Duff reaction / 2.2: Duff reaction;
DOI:10.1039/c1cc14653j