1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

Base Information

Chemical Name:1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol
CAS No.:1049809-38-2
Molecular Formula:C₂₈H₃₁Cl₂N₅O₃S
Molecular Weight:588.558
Hs Code.:

Synonyms:1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

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Chemical Property of 1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

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Technology Process of 1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

There total 2 articles about 1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1049809-37-1
4-(3-{3-[4-chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-2-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1049809-38-2
1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

Guidance literature:: 4-(3-{3-[4-chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-2-hydroxy-propyl)-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In methanol; dichloromethane; SiO₂;

Reference yield:

: 873-73-4
4-n-chlorophenylacetylene

: 1198184-18-7
C₂₀H₂₇ClIN₅O₃S

: 1049809-38-2
1-{3-[4-Chloro-3-(4-chloro-phenylethynyl)-phenyl]-5-methanesulfonyl-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl}-3-piperazin-1-yl-propan-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2009.09.013