di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate

Base Information

• Chemical Name: di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate
• CAS No.: 865850-70-0
• Molecular Formula: C₂₃H₃₁NO₆
• Molecular Weight: 417.502
• Mol file: 865850-70-0.mol

Synonyms:di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate

Chemical Property of di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate

There total 1 articles about di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl 3-hydroxy-3-methyl-1-(1'R-phenylethyl)pyrrolidin-5-one-2,2-dicarboxylate → di-tert-butyl 3R-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate + di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate (865850-70-0)

Guidance literature:

With sodium iodide; In acetonitrile; at 85 ℃; optical yield given as %de; diastereoselective reaction; Electrochemical reaction;

DOI:10.1016/j.tet.2009.09.087

Reference yield: 83.0%

di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate (865850-70-0) → 3S-(1'R-hydroxyethyl)-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylic acid di-tert-butyl ester (865850-72-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at -20 ℃; for 4h; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tet.2009.09.087

Reference yield:

di-tert-butyl 3S-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate (865850-70-0) → di-tert-butyl 3R-acetyl-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylate

Guidance literature:

With potassium carbonate; In chloroform-d1; at 25 ℃;

DOI:10.1016/j.tet.2009.09.087

Downstream raw materials:

3S-(1'R-hydroxyethyl)-1-(1'R-phenylethyl)azetidin-2-one-4,4-dicarboxylic acid di-tert-butyl ester