(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

Base Information

Chemical Name:(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate
CAS No.:137820-98-5
Molecular Formula:C₂₁H₂₂INO₃
Molecular Weight:463.315
Hs Code.:

Synonyms:(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

Chemical Property:

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Technology Process of (S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

There total 3 articles about (S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137820-95-2
(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetic acid

: 3684-26-2,25333-42-0,34583-34-1,1619-34-7
(S)-quinuclidin-3-ol

: 137820-98-5
(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

Guidance literature:: With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) DMF, RT, 1 h, 2.) DMF, RT, 15 h;
DOI:10.1016/S0957-4166(00)82085-6

Reference yield:

: 126923-27-1
(R)-(+)-α-hydroxy-α-(4-nitrophenyl)-α-phenylacetic acid

: 137820-98-5
(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / hydrazine / Raney-Ni / ethanol / 18 h / Ambient temperature

2: 1.) sodium nitrite, aq. HCl, 2.) KI / 1.) 0 deg C, 30 min, 2.) water, a) 0 deg C, 1 h, b) RT, 1 h

3: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, RT, 1 h, 2.) DMF, RT, 15 h

With hydrogenchloride; 1,1'-carbonyldiimidazole; potassium iodide; hydrazine; sodium nitrite; nickel; In ethanol;
DOI:10.1016/S0957-4166(00)82085-6

Reference yield:

: 137820-94-1
(R)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetic acid

: 137820-98-5
(S)-1-azabicyclo<2.2.2>-oct-3-yl-(R)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium nitrite, aq. HCl, 2.) KI / 1.) 0 deg C, 30 min, 2.) water, a) 0 deg C, 1 h, b) RT, 1 h

2: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, RT, 1 h, 2.) DMF, RT, 15 h

With hydrogenchloride; 1,1'-carbonyldiimidazole; potassium iodide; sodium nitrite;
DOI:10.1016/S0957-4166(00)82085-6