1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane>

Base Information

• Chemical Name: 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane>
• CAS No.: 166303-19-1
• Molecular Formula: C₇₂H₉₄N₈O₁₂S₆
• Molecular Weight: 1455.98
• Mol file: 166303-19-1.mol

Synonyms:1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane>

Chemical Property of 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane>

There total 3 articles about 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,5-dibromomethyl-p-xylene (35168-62-8) + tris-(p-toluenesulfonyl)-1,4,8,11-tetraazacyclotetradecane (104395-69-9) → 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane> (166303-19-1)

Guidance literature:

With potassium carbonate; In acetonitrile; for 18h; Heating;

DOI:10.1021/jm00002a019

Reference yield:

1,4-bis(hydroxymethyl)-2,5-dimethylbenzene (22530-09-2) → 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane> (166303-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 48percent aq. HBr, Ac₂O

2: 97 percent / K₂CO₂ / acetonitrile / 18 h / Heating

With hydrogen bromide; acetic anhydride; potassium carbonate; In acetonitrile;

DOI:10.1021/jm00002a019

Reference yield:

2,5-dimethylterephthalic acid (6051-66-7) → 1,1'-<2,5-dimethyl-1,4-phenylenebis(methylene)>bis<4,8,11-tris(p-tolylsulfonyl)-1,4,8,11-tetraazacyclotetradecane> (166303-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*THF

2: 48percent aq. HBr, Ac₂O

3: 97 percent / K₂CO₂ / acetonitrile / 18 h / Heating

With borane-THF; hydrogen bromide; acetic anhydride; potassium carbonate; In acetonitrile;

DOI:10.1021/jm00002a019

upstream raw materials:

2,5-dibromomethyl-p-xylene

tris-(p-toluenesulfonyl)-1,4,8,11-tetraazacyclotetradecane

1,4-bis(hydroxymethyl)-2,5-dimethylbenzene

2,5-dimethylterephthalic acid