1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

Base Information

Chemical Name:1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea
CAS No.:1408075-37-5
Molecular Formula:C₂₅H₂₅Cl₂N₇O
Molecular Weight:510.426
Hs Code.:

Synonyms:1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

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Technology Process of 1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

There total 5 articles about 1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1408075-33-1
tert-butyl N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}carbamate

: 109-90-0
ethyl isocyanate

: 1408075-37-5
1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; for 16h;

Reference yield: 56.0%

: 1408075-34-2
1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-piperidin-4-amine

: 109-90-0
ethyl isocyanate

: 1408075-37-5
1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; for 16h;
DOI:10.1021/jm301181r

Reference yield:

: 686344-50-3
6-chloro-9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purine

: 1408075-37-5
1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]piperidin-4-yl}-3-ethylurea

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 16 h

3: triethylamine / tetrahydrofuran / 16 h

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm301181r