(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide
CAS No.:459143-45-4
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

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Technology Process of (1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

There total 3 articles about (1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 925-90-6
ethylmagnesium bromide

: 459143-37-4
(1S,2R)-1-phenyl-2-formyl-N,N-dimethylcyclopropanecarboxamide

: 459143-45-4
(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at -15 ℃; for 3h;
DOI:10.1016/S0968-0896(02)00030-5

Reference yield:

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 459143-45-4
(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / AlCl₃ / CH₂Cl₂; tetrahydrofuran / 24 h / 20 °C

2: 91 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

3: 93 percent / tetrahydrofuran; diethyl ether / 3 h / -15 °C

With aluminium trichloride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 2: Swern oxidation / 3: Grignard reaction;
DOI:10.1016/S0968-0896(02)00030-5

Reference yield:

: 459143-30-7
(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-dimethylcyclopropanecarboxamide

: 459143-45-4
(1S,2R)-1-phenyl-2-[(S)-1-hydroxtpropyl]-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

2: 93 percent / tetrahydrofuran; diethyl ether / 3 h / -15 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Swern oxidation / 2: Grignard reaction;
DOI:10.1016/S0968-0896(02)00030-5