Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI)

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI)
• CAS No.: 204457-43-2
• Molecular Formula: C₇H₉FO₃
• Molecular Weight: 160.145
• Mol file: 204457-43-2.mol

Synonyms:Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI)

Chemical Property of Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI)

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI)

There total 4 articles about Cyclopentanecarboxylic acid, 1-fluoro-2-oxo-, methyl ester, (-)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → (R)-methyl 1-fluoro-2-oxocyclopentanecarboxylate (204457-43-2)

Guidance literature:

With NFSI; C₃₅H₅₂N₂O₃; cobalt acetylacetonate; In diethyl ether; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1246/cl.2010.466

Reference yield: 48.0%

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → methyl 1-fluoro-2-oxocyclopentanecarboxylate (141420-01-1,204457-43-2)

Guidance literature:

With titanium(IV) isopropylate; N-fluorobis(methanesulfonyl)imide; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c5gc02612a

Reference yield:

methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → (R)-methyl 1-fluoro-2-oxocyclopentanecarboxylate (204457-43-2) + (S)-methyl 1-fluoro-2-oxocyclopentanecarboxylate (204457-43-2)

Guidance literature:

With chiral 1,1-binaphthyl-based scandium salt; N-fluoropyridinium triflate; In toluene; at 0 ℃; for 24h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2005.12.029

upstream raw materials:

methyl 2-oxocyclopentane-1-carboxylate